In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Plaquenil manufacturer covis Chloroquine definition May 21, 2010 I was diagnosed almost 2yrs ago with Lupus, SLE & subacute subcutaneous. The plaquenil made me lose my hair immediately. When it came back in most of it came in white which I read that the medicine can bleach your hair. Then last year I noticed areas on my legs that are brown or maybe it's that my skin has been bleached in areas and is very white. I've been on Plaquenil 400mg a day for almost 4 years. I haven't noticed any skin discoloration but my hair turned grey at a very young age and I've always kept it natural, but as of late it is turning yellowish and my hair dresser thinks it is from the medication. I checked on Mayo Clinic and one of the side effects is hair bleaching. Some medications, such as plaquenil and minocycline, can cause permanent dark skin plaques, which resemble black and blue marks similar to morphea scleroderma. Cosmetically, pigmentation differences can be covered up with corrective cosmetics, such as Dermablend. Drug-Induced Hyperpigmentation caused by Minocycline Minocin Antibiotic Selected from data included with permission and copyrighted by First Databank, Inc. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Plaquenil skin pigmentation Plaquenil and spots on skin DailyStrength, Plaquenil and skin discoloration - Sjogren's World Can plaquenil cause numbness in tailbone area and legsHydroxychloroquine buy onlinePlaquenil e nauseaHydroxychloroquine pigmentation Find information about common, infrequent and rare side effects of Plaquenil Oral. Common and Rare Side Effects for Plaquenil Oral. Systemic Scleroderma Skin Involvement Hyperpigmentation and.. Drug-induced hyperpigmentation DermNet NZ. One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do. dizziness, skin rash or black spots when you look at things. Most side effects will go away when your body gets used to the medicine. Tell your doctor if you have these side effects. A lower dose may stop them. Do not lower the dose on your own. Aug 18, 2011 Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong.