Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil substitute Plaquenil medication guide Pharmacokinetics chloroquine mice Plaquenil pregnancy drug class Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine alone taken weekly is recommended for travelers who cannot use mefloquine or doxycycline, especially pregnant women and children under 15 kg. Travelers who elect to use chloroquine except those with histories of sulfonamide intolerance should be given a treatment dose of FansidarR to be carried during travel. Chloroquine contains the lysosomotropic character that is believed to account for much of its antimalarial activity; the drug concentrates in the acidic food vacuole of the parasite and interferes with essential processes. It is so dangerous because it contains toxic to cure malaria and amebiasis. Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria. Chloroquine synthetic Could an old malaria drug help fight the new coronavirus?, Recommendations for the Prevention of Malaria Among Travelers Chloroquine and proguanil side effectsChloroquine gg 260Plaquenil dreamsActavis pharma plaquenil A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Chloroquine Indications, Side Effects, Warnings -. The synthetic process used to make Chloroquine -. A New Synthesis of Chloroquine Journal of the American.. Chloroquine is the synthetic version of the natural quinine – i just wonder if quinine could have the same impact on coronovirus. Quinine is on WHO`s list of accepted antimarial drugs – like choroquine. Chloroquine is a member of quinolone family and is a weak intercalating agent. Chloroquine is used for treating amebiasis, rheumatoid arthritis, discoid and systemic lupus erythematosus. Application DNA intercalator. Also used to increase transfection efficiency. Chloroquine diphosphate salt has been used • in in vitro antiplasmodial assays Chloroquine is a synthetic quinoline being used as an antimalaria and antirheumatoid agent. Several cases of hepatotoxicity have been reported with the use of chloroquine. However, the mechanisms of its hepatotoxic effect is unknown. The purpose of this study was to investigate the cytotoxic mechanism of chloroquine.