It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction. I really liked the Arava, but I I am now on MTX and Simponi now. The disease is also systemic in that it often also affects many extra-articular tissues throughout the body including the skin, blood vessels, heart, lungs, and... I was on the Orencia when I was on the above two you mentioned. Methotrexate or plaquenil How to stop itching from plaquenil How to dissolve chloroquine Plaquenil and joint repla Feb 29, 2008 I had a lot of problems with Methotrexate as well, but I am not having the same issues with arava which I was afraid of. The plaquenil worked wonders for me and I took it solo for about 2 years, but after a while I was starting to have a severe flare that wouldn't let up - so we gave it a push with the Arava. i'm doing quite well with the. Nov 01, 2018 CHICAGO – Combination therapy with leflunomide and hydroxychloroquine met all goals for efficacy, safety, and tolerability among patients with primary Sjögren’s syndrome in a randomized, placebo-controlled pilot study, lending support to evidence suggesting the two drugs have additive benefits. Apr 13, 2005 The Combination of Leflunomide Arava and Methotrexate is Safe & Efficacious for the Treatment of Rheumatoid Arthritis April 13, 2005 By Arthritis Center Methotrexate MTX, an anti-metabolite that inhibits purine pathways, has been the hallmark of standard of care for many years in the treatment of rheumatoid arthritis RA. The doctor then kept me on my plaquenil and added Leflunomide (Arava) to replace the methotrexate. I started out on the Plaquenil and Methotrexate oral and while my RA symptoms were reduced some, the methotrexate made me extremely ill for 2 days after I took each dose. Arava and plaquenil together Interactions between Arava Oral and leflunomide-warfarin, Leflunomide-hydroxychloroquine combo shows promise in primary. Plaquenil anxiety side effect This study was designed to evaluate the efficacy of the combination of methotrexate and hydroxychloroquine with leflunomide in the treatment of active rheumatoid arthritis over a period of 12 weeks. A significant change in disease activity score was seen in both the groups at 6 and 12 weeks after initiating therapy with the investigative drugs. Evaluation of efficacy of combination of methotrexate and.. The Combination of Leflunomide Arava. - Arthritis Information. Hydroxychloroquine oral and leflunomide oral Drug.. Vaccinations, warfarin, and corticosteroids are among the many products that may react with Arava. This eMedTV resource lists other drugs that may cause interactions with Arava and describes what may happen if these medications are taken together. Leflunomide, a disease-modifying anti-rheumatic drug DMARD that inhibits DNA synthesis, is a common alternative to MTX. Whether leflunomide can be used as an alternative for MTX in combination with SSZ and HCQ has not previously been studied. Compare Arava vs. Plaquenil, which is better for uses like RA and Arthritis. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Plaquenil 3.7/5 over Arava 3.2/5 in overall satisfaction.