Chloroquine endosome

Discussion in 'Canada Pharmaceuticals Online' started by defka, 14-Mar-2020.

  1. Serge_vet New Member

    Chloroquine endosome


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Usual Adult Dose for Malaria Prophylaxis. 500 mg chloroquine phosphate 300 mg base orally on the same day each week Comments-If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate 600 mg base may be taken orally in 2 divided doses, 6 hours apart. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Chloroquine blocks the virus's ability to acidify endosomes and release its RNA into the cell, which is a critical step for most viruses to begin their infection.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine endosome

    Inhibition of Endosomal/Lysosomal Degradation Increases the., Chloroquine Oral Uses, Side Effects, Interactions, Pictures.

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  7. Chloroquine is a weakly basic compound and is able to increase pH in endosome. We speculated that chloroquine prevented the disassembly of viral particles to release viral RNA from endosome to cytoplasm for replication.

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    Chloroquine is a weak base that can rapidly penetrate the plasma membrane, accumulate in acidic vesicles and increase the pH of the acidic compartment Maxfield 1982; Mellman, Fuchs et al. 1986. Preventing endosome acidification may subsequently inhibit hydrolytic enzymes such as proteases and nucleases Cotten, Längle-Rouault et al. 1990. Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best. Jan 23, 2017 Inhibitors of endosome acidification such as chloroquine block the viral permeabilization event in endosome Stuart and Brown 2006. Treatment with chloroquine significantly reduces the replication of caliciviruses including porcine enteric calicivirus, murine norovirus‐1 and feline calicivirus in vitro Shivanna et al. 2014.

     
  8. Strem New Member

    Common sites of involvement are the sides, front and lower back of the scalp. The role of hydroxychloroquine in the treatment of lichen. Full text Therapeutic management of classic lichen. Hydroxychloroquine Side Effects Common, Severe, Long Term.
     
  9. Renter.ru Moderator

    Plaquenil Oral Uses, Side Effects, Interactions. Plaquenil. Uses. Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of. Side Effects. Precautions. Interactions.

    Plaquenil side effects" Lupus Community - Support Group
     
  10. rush1 XenForo Moderator

    Plaquenil - FDA prescribing information, side effects and uses Renal clearance in rheumatoid arthritis RA patients taking Plaquenil for at least six months seemed to be similar to that of the single dose studies in volunteers, suggesting that no change occurs with chronic dosing. Range for renal clearance of unchanged drug was approximately 16 to 30%.

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