Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Concordia pharmaceuticals plaquenil Plaquenil liver toxicity How long does it take for plaquenil to work. how long does it take for this medication to work and how long before its out of your system. Tell me where you live and I will work out how. It may take up to six months before the full benefits of Plaquenil are realized. Dosage The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. I am having severe RA again in my feet and ankles. Happens about at the end of every month now. Even since I've started the meds. I am on Plaquenil right now, but I am wondering how well it works since my pain has come back. I have heard some people switch over to Methotrxate if the Plaquenil doesn't work. 4 replies Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. How long before plaquenil works Coming Off Plaquenil questions - Sclero Forums MAIN., Taking Plaquenil for Rheumatoid Arthritis Hydroxychloroquine can it shrink spleenChloroquine mechanism of action cancerQuinoric or plaquenilPlaquenil cause weight loss I know I've asked this question before, but with so many new people and so much time that's passed, I thought I'd ask again. How long did it take for Plaquenil to become effective for you? Meaning, when did you start to feel some relief from your lupus symptoms after you started taking. Plaquenil.long do I have to wait? DailyStrength. Arthritis Board Index plaquenil how long to work. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Hydroxychloroquine doesn’t work immediately. It may be 12 weeks or longer before you notice any benefit. Because it's a long-term treatment it's important to keep taking hydroxychloroquine unless you have severe side-effects even if it doesn't seem to be working at first; even when your symptoms improve to help keep the disease under. Aug 16, 2010 Most people say about 6 months. It works over time. It's pretty suttle. One day all the sudden you will notice that your arms or legs or feet don't feel as bad as they used to. Not that it is a cure all but it usually does help. I searched the board for info on this drug, but couldn't find a thread that answered my question. How long was it until you started to see some benefit from pilocarpine? I am starting at a low dose of 5mg x 3 daily. The handout says it could take 12 weeks before it starts to work, and I have only been on it 3 days. I want it to work NOW.