Long-term progression of hydroxychloroquine retinopathy off the drug

Discussion in 'Canada Pharmaceuticals Online' started by antar1, 24-Feb-2020.

  1. soljenicenxp New Member

    Long-term progression of hydroxychloroquine retinopathy off the drug


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    Baseline and periodic screening for retinopathy is necessary for rheumatologic uses and in long-term therapy eg, 1 to 5 years depending on patient risk factors AAO Marmor 2016; Travassos 2019. Tolerability GI upset nausea, vomiting, diarrhea is a common adverse effect. Dividing doses, taking with food, and, if appropriate, gradual dose escalation in treating rheumatologic diseases may improve tolerability Wallace 2019. Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1 Importance Hydroxychloroquine sulfate retinopathy can progress after the drug is stopped. It is not clear how this relates to the stage of retinopathy or whether early screening with modern.

    Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus.

    Long-term progression of hydroxychloroquine retinopathy off the drug

    Hydroxychloroquine Side Effects Common, Severe, Long Term -, Hydroxychloroquine toxicity - EyeWiki

  2. Hydroxychloroquine mechanism of action in rheumatoid arthritis
  3. Retinopathy is uncommon if the recommended daily dose is not exceeded. It is usually reversible if therapy is discontinued. If allowed to develop, there may be a risk of progression even after treatment withdrawal.

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    Melles RB, Marmor MF. The risk of toxic retinopathy in patients on long-term hydroxychloroquine therapy. JAMA Ophthalmol. 2014 Dec;132121453-60. 6. Melles RB, Marmor MF. Pericentral retinopathy and racial differences in hydroxychloroquine toxicity. Ophthalmology 2015;1221110-6. 7. Pham B, et al. Long-term progression of hydroxychloroquine retinopathy off the drug. Presented at Association for Research in Vision and Ophthalmology annual meeting; April 29-May 3, 2018; Honolulu. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye.

     
  4. SibirLab New Member

    Sometimes it’s very mild and unnoticeable but for some, it can be quite severe and cause considerable anguish. Plaquenil and hair growth? Or loss? - Lupus - Inspire Plaquenil and hair loss Mayo Clinic Connect Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
  5. Max C Moderator

    Plaquenil and Depression/Anxiety - Symptoms and Medical Treatments. After several months off of plaquenil, I went back on it, deciding to stick with the 100 mg per day. I have always been very sensitive to meds. Again my fatigue improved and I began to be able to do more. But again- over several months time my anxiety, depression, and sense of distance from personal relationships began to worsen.

    Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis
     
  6. Kiki XenForo Moderator

    Will you have Opiate withdrawal with Plaquenil - eHealthMe The study is based on hydroxychloroquine sulfate the active ingredients of Plaquenil and Plaquenil the brand name. Other drugs that have the same active ingredients e.g. generic drugs are not considered. Synonyms of Opiate withdrawal are also considered in the study.

    Hydroxychloroquine MedlinePlus Drug Information