Lasix and side effects

Discussion in 'Canadapharmacy' started by zzv, 05-Sep-2019.

  1. Shelana Well-Known Member

    Lasix and side effects


    It is also used for liver cirrhosis, kidney impairment, nephrotic syndrome, in adjunct therapy for swelling of the brain or lungs where rapid diuresis is required (IV injection), and in the management of severe hypercalcemia in combination with adequate rehydration. Furosemide also can lead to gout caused by hyperuricemia. The tendency, as for all loop diuretics, to cause low serum potassium concentration (hypokalemia) has given rise to combination products, either with potassium or with the potassium-sparing diuretic amiloride (Co-amilofruse). Other electrolyte abnormalities that can result from furosemide use include hyponatremia, hypochloremia, hypomagnesemia, and hypocalcemia. Furosemide, like other loop diuretics, acts by inhibiting the luminal Na-K-Cl cotransporter in the thick ascending limb of the loop of Henle, by binding to the chloride transport channel, thus causing sodium, chloride, and potassium loss in urine. The action on the distal tubules is independent of any inhibitory effect on carbonic anhydrase or aldosterone; it also abolishes the corticomedullary osmotic gradient and blocks negative, as well as positive, free water clearance. Because of the large Na Cl absorptive capacity of the loop of Henle, diuresis is not limited by development of acidosis, as it is with the carbonic anhydrase inhibitors. Additionally, furosemide is a noncompetitive subtype-specific blocker of GABA-A receptors. Some of the brand names under which furosemide is marketed include: Aisemide, Apo-Furosemide, Beronald, Desdemin, Discoid, Diural, Diurapid, Dryptal, Durafurid, Edemid, Errolon, Eutensin, Flusapex, Frudix, Frusetic, Frusid, Fulsix, Fuluvamide, Furesis, Furix, Furo-Puren, Furon, Furosedon, Fusid.frusone, Hydro-rapid, Impugan, Katlex, Lasilix, Lasix, Lodix, Lowpston, Macasirool, Mirfat, Nicorol, Odemase, Oedemex, Profemin, Rosemide, Rusyde, Salix, Seguril, Teva-Furosemide, Trofurit, Uremide, and Urex. Furosemide belongs to a group of medicines called loop diuretics (also known as water pills). Furosemide is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine. Furosemide is also used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure.

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    Diurectics are often the first medication to try for high blood pressure hypertension. They help your body get rid of extra water and salt. What should. General. Pronunciation fur-oh-se-mide. furosemide. Trade Names. Lasix. Ther. TIME/ACTION PROFILE diuretic effect. Adverse Reactions/Side Effects. You may experience some or none of the side effects of Lasix described in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have side effects from a medicine that you have never tried.

    Along with its needed effects, furosemide (the active ingredient contained in Lasix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Lasix (furosemide)." sanofi-aventis , Bridgewater, NJ. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Check with your doctor immediately if any of the following side effects occur while taking furosemide: Some side effects of furosemide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to furosemide: compounding powder, injectable solution, intravenous solution, oral liquid, oral solution, oral tablet Common (1% to 10%): Hyponatremia, hypochloremia, hypokalemia, blood cholesterol increased, blood uric acid increased, gout Uncommon (0.1% to 1%): Thirst, glucose tolerance decreased Rare (0.01% to 0.1%): Anorexia, serum triglycerides increased Frequency not reported: Hyperglycemia, diabetes mellitus, hyperuricemia, metabolic alkalosis, hypocalcemia, hypomagnesemia, hypovolemia, dehydration, tetany, serum potassium decreased, Pseudo-Bartter syndrome, electrolyte disturbances, serum calcium decreased Common (1% to 10%): Hemoconcentration Uncommon (0.1% to 1%): Thrombocytopenia Rare (0.01% to 0.1%): Eosinophilia, leukopenia, bone marrow depression Very rare (less than 0.01%): Hemolytic anemia, aplastic anemia, agranulocytosis Frequency not reported: Anemia, thrombophilia Uncommon (0.1% to 1%): Pruritus, bullous exanthema, rash, urticaria, purpura, erythema multiforme, exfoliative dermatitis, photosensitivity Rare (less than 0.1%): Lyell's syndrome and Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, drug rash with eosinophilia and systemic symptoms Frequency not reported: Toxic epidermal necrolysis, bullous pemphigoid, sweating Uncommon (0.1% to 1%): Dry mouth, nausea, bowel motility disturbances, vomiting, diarrhea, constipation Rare (less than 0.1%): Gastric distress, acute pancreatitis Frequency not reported: Pancreatitis, oral and gastric irritation, cramping Uncommon (0.1% to 1%): Blood creatinine increased, urea increased Rare (less than 0.1%): Interstitial nephritis, acute renal failure Frequency not reported: Nephrocalcinosis in premature infants, nephrolithiasis in premature infants, GFR decreased, tubulointerstitial nephritis Uncommon (0.1% to 1%): Deafness, fatigue Rare (less than 0.1%): Sensation of pressure in the head, dysacusis, asthenia, fever, febrile conditions, malaise Frequency not reported: Weakness, sudden death, hearing disorders, hearing loss, paradoxical swelling Uncommon (0.1% to 1%): Cardiac arrhythmia Rare (less than 0.1%): Vasculitis Frequency not reported: Systemic vasculitis, necrotizing angiitis, orthostatic hypotension, thrombophlebitis, acute hypotension, circulatory collapse, persistent patent ductus arteriosus during the first few weeks of life in premature infants with respiratory distress syndrome, blood pressure decreased, shock, hypotension, thrombosis, orthostatic blood pressure decreased Rare (0.01% to 0.1%): Paresthesia, vertigo, dizziness, sleepiness, tinnitus, hyperosmolar coma Frequency not reported: Hepatic encephalopathy, headache, fainting and loss of consciousness, drowsiness, lethargy, sweet taste1. Absorption: 60–67% absorbed after oral administration (↓ in acute HF and in renal failure); also absorbed from IM sites. Metabolism and Excretion: Minimally metabolized by liver, some nonhepatic metabolism, some renal excretion as unchanged drug. TIME/ACTION PROFILE (diuretic effect)CNS: blurred vision, dizziness, headache, vertigo EENT: hearing loss, tinnitus CV: hypotension GI: anorexia, constipation, diarrhea, dry mouth, dyspepsia, ↑ liver enzymes, nausea, pancreatitis, vomiting GU: ↑ BUN, excessive urination, nephrocalcinosis Derm: Edema PO: (Adults) 20–80 mg/day as a single dose initially, may repeat in 6–8 hr; may ↑ dose by 20–40 mg q 6–8 hr until desired response. Distribution: Crosses placenta, enters breast milk. Maintenance doses may be given once or twice daily (doses up to 2.5 g/day have been used in patients with HF or renal disease). Hypertension– 40 twice daily initially (when added to regimen, ↓ dose of other antihypertensives by 50%); adjust further dosing based on response; Hypercalcemia– 120 mg/day in 1–3 doses. PO: (Children 1 mo): 2 mg/kg as a single dose; may be ↑ by 1–2 mg/kg q 6–8 hr (maximum dose = 6 mg/kg). IM: IV: (Adults) 20–40 mg, may repeat in 1–2 hr and ↑ by 20 mg every 1–2 hr until response is obtained, maintenance dose may be given q 6–12 hr; Continuous infusion– Bolus 0.1 mg/kg followed by 0.1 mg/kg/hr, double q 2 hr to a maximum of 0.4 mg/kg/hr. IM: IV: Children 1–2 mg/kg/dose q 6–12 hr; Continuous infusion– 0.05 mg/kg/hr, titrate to clinical effect. Hypertension PO: (Adults) 40 twice daily initially (when added to regimen, ↓ dose of other antihypertensives by 50%); adjust further dosing based on response. Tablets: 20 mg, 40 mg, 80 mg, 500 mg Cost: Generic: 20 mg $6.50/100, 40 mg $7.11/100, 80 mg $10.83/100Oral solution (10 mg/m L–orange flavor, 8 mg/m L–pineapple–peach flavor): 8 mg/m L, 10 mg/m LCost: Generic: 10 mg/m L $10.40/60 m LSolution for injection: 10 mg/m LLab Test Considerations: Monitor electrolytes, renal and hepatic function, serum glucose, and uric acid levels before and periodically throughout therapy. May cause ↓ serum sodium, calcium, and magnesium concentrations. May also cause ↑ BUN, serum glucose, creatinine, and uric acid levels.furosemide is a sample topic from the Davis's Drug Guide.

    Lasix and side effects

    Furosemide side effects - from FDA reports - eHealthMe, Furosemide Davis's Drug Guide

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  7. Furosemide, sold under the brand name Lasix among others, is a medication used to treat fluid. Common side effects include low blood pressure with standing, ringing in the ears, and sensitivity to sunlight. Potentially serious side effects.

    • Furosemide - Wikipedia.
    • Lasix Side Effects - Blood Pressure Home Page.
    • Furosemide Side Effects, Interactions, Uses & Drug Imprint.

    Mar 26, 2018. Lasix - Get up-to-date information on Lasix side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Lasix. FUROSEMIDE is a diuretic. It helps you make more urine and to lose salt and excess water from your body. This medicine is used to treat high blood pressure, and edema or swelling from heart, kidney, or liver disease. Lasix side effects and concerns 1,059 different concerns were found, out of 53,572 posts about Lasix. Click on the topics below to find out what patients said about each issue.

     
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