Derm Net NZ Medical Editor: Dr Delwyn Dyall-Smith, Dermatologist, Wagga Wagga, NSW, Australia. However, following an identical dose of hydroxychloroquine and chloroquine, tissue levels of chloroquine are 2.5 times those of hydroxychloroquine. Derm Net NZ Editor in Chief: Adjunct Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. Hydroxychloroquine is preferred due to its safer profile. Artemisia annua taken with hydroxychloroquine 4 aminoquinolines chloroquine Stopping and starting plaquenil A case of hair depigmentation induced by chloroquine diphosphate subacute overdosage in an 11-year-old patient with dermatomyositis is presented. Normal coloured hair growth occurred after normalisation of chloroquine dosage. The anti-malarial agent chloroquine diphosphate, which is also used to treat immunological, dermatological, and rheumatological disorders, usually causes pigmentary changes in the oral mucosa. This report presents a case of palate pigmentation related to the prolonged use of chloroquine diphosphate caused by the deposition of drug metabolites in the mucosa. Effects of chloroquine? Chloroquine is a relatively well-tolerated. medicine. The most common adverse reactions reported are stomach pain, nausea, vomiting, and headache. These side effects can often be lessened by taking chloroquine with food. Chloroquine may also cause itching in some people. All medicines may have some side effects. Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. If there is a of hydroxychloroquine, although studies have not usually confirmed this clinical impression. Chloroquine pigmentation Hyperpigmentation of hard palate induced by chloroquine therapy, Palate Hyperpigmentation Caused by Prolonged Use of the. Chloroquine used whereQuinacrine with hydroxychloroquine lupus profundus About 25% of patients receiving chloroquine or hydroxychloroquine for several years develop bluish-grey pigmentation on face, neck and sometimes lower legs and forearms Continuous long-term use may lead to blue-black patches, especially in sun-exposed areas Drug-induced hyperpigmentation DermNet NZ. Medicines for the Prevention of Malaria While Traveling.. Disorders of Oral Pigmentation Background.. Mucocutaneous hyperpigmentation because of anti-malarial therapy has been reported since World War II 2; however, HCQ-associated hyperpigmentation seems to be less common than with other antimalarials such as chloroquine 3,4onset of HCQ-associated hyperpigmentation ranges from 3 months to 22 years following the initiation of therapy, with a median of 6.1 years 1. Multiple pathologic mechanisms are responsible for drug-induced pigmentation disorders. Compared with the immunological etiology underlying many drug allergies, most cases of pharmacologic pigmentation are not immunologically mediated. Thank you for your interest in spreading the word about The BMJ. NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail.