As a result, the body produces antibodies that inflict cell damage, most commonly targeting joints, skin, kidneys and the nervous system. I recently started taking it in September and it seems like after about 5-10 minutes of taking it, I feel super tired and sleepy. Maybe try taking it with food and see if that helps. if your symptoms persist, you may need a change of dose. Join the group and find support for coping with lupus. I have read about the side effects and I do get the stomache discomfort but is the tiredness normal? but you may want to make sure your not taking too much. hugs I have been taking Plaquenil for quite a few years now, I don't think it's the Plaquenil making you tired...good ol' Lupus. I take 400mg a day and now 2 x Cyclosporin...to mention all the other stuff (I swear when I walk you can hear the rattle! Hi Phoebe, I have been on plaquenil for many years and have not experienced a sudden onset of fatigue after taking it. As Melissa stated plaquenil typically comes in 200mg tablets and 800 mg really seems like an aweful huge dose. Did your doctor tell you to take 2 tabs twice daily or you base on the label on your med bottle. Antipaludéen de synthèse plaquenil Hydroxychloroquine and muscle pain Plaquenil low platelets How do you know if plaquenil is working Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory. WebMD explains the causes, symptoms, and treatment of Sjogren's syndrome, a condition in which your eyes, mouth, and other parts of your body get dried out. Feb 09, 2012 I have never been told exactly what Plaquenil does for SLE. I just know my Rheumatologist put me on it. I stopped going to him because he was so negative and I lost an entire year with my family and friends because I was scared to death that being outside in the heat or cold would make me worse. I've also tried to take 1 pill every couple of hours and that still doesn't prevent the fatigue feeling.... I usually take one in the morning and one at night. So far, I don't see any difference, but I guess it takes time. You might want to double check with your rheumy or prescribing doctor to inquire about your current dose and advise of your symptoms. I don't think there is a 100 mg tab, unless it is specially compounded. I have to take two pills in the am and two pills i the pm...sometimes I almost want to just skip the dose in the morning because it makes me feel worse than if I don't take anything. If so, I have never heard of anyone being on 800mg of plaquenil. You can look up the therapeutic doses online and it will tell you the highest dose you can take. Maybe that is why you are so tired after taking them. Taking it with food stops you feeling sick, and yes it takes a long time to kick in... While those of us with lupus never truly find anything to relieve fatigue, plaquenil is suppose to help with fatigue rather than create more from what I understand. The most I have ever taken is 400mg, I am currently on 300mg. I think there is probably some error or misunderstanding or miscommunication going on. Does plaquenil make a virus worse Plaquenil Side Effects Common, Severe, Long Term -, Sjogren's Syndrome Symptoms, Causes, Diagnosis, Treatment Can i drink if taking plaquenil I have a lot of symptoms from Plaquenil, but for me I only notice a slight change in how it affects me. I went off of it for two months, and my Lupus got way worse. When I went back on it helped, but it doesn’t do as much as I would like it too. Does Plaquenil actually work for you? autoimmunity. Systemic Lupus Erythematosus - Does anyone else take.. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. PLAQUENIL brand-name is fantastic, however the generic Hydroxychloroquine is awful! I took brand-name for 2 years and my SLE was well-managed and I wasn’t having side effects. Then the brand name was switched by my pharmacy to the generic hydroxychloroquine and it was one of the worst experiences. I have a question to ask anyone on plaquenil. After taking it, does it make you feel all of sudden really tired? I recently started taking it in September and it seems like after about 5-10 minutes of taking it, I feel super tired and sleepy. I have read about the side effects and I do get the stomache discomfort but is the tiredness normal? Aug 29, 2014 One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur.