Listing a study does not mean it has been evaluated by the U. The epidermal growth factor receptor (EGFR) signaling pathway plays a central role in the neoplastic transformation of NSCLC and promotes cancer cell survival, metastasis, and angiogenesis. Non-small cell lung cancer (NSCLC) is the most common cause of cancer mortality in men and women in Singapore. Plaquenil and optic neuropathy Chloroquine antibody Hydroxychloroquine side effectt Jun 01, 2018 Modulation of autophagy with hydroxychloroquine in patients with advanced non-small cell lung cancer NSCLC A phase Ib study. Background A potential resistance mechanism to chemotherapy in NSCLC is through activation of cell survival pathways such as autophagy. Cancer plus an additional drug, hydroxychloroquine. The standard treatment for lung cancer. being used includes 2 chemotherapy drugs, called paclitaxel and carboplatin, plus a drug. that targets blood vessels, called bevacizumab also known as avastin. Hydroxychloroquine and Gefitinib to Treat Lung Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Over the last three years, the FDA has approved two drugs for salvage treatment of NSCLC, gefitinib (Iressa ®, formerly known as ZD1839) and erlotinib (Tarceva ®, formerly known as OSI-774). The predominance of EGFR signaling in NSCLC makes the pathway an attractive candidate for the development of targeted therapeutics. Hydroxychloroquine lung cancer Common and Rare Side Effects for Hydroxychloroquine Oral, Hydroxychloroquine + Carboplatin, Paclitaxel and Bevacizumab in Non. Ra treatment plaquenil methotrexateTrialnet hydroxychloroquineCan chloroquine terminate pregnancy Hydroxychloroquine may inactivate these pathways and results in the death of pancreatic cancer cells. Hydroxychloroquine in Metastatic Estrogen Receptor-Positive Breast Cancer Progressing on Hormonal Therapy. Hydroxychloroquine With or Without Erlotinib in Advanced Non-small Cell Lung Cancer NSCLC Chloroquine & Hydroxychloroquine supporting chemo effectiveness and.. Hydroxychloroquine and Gefitinib to Treat Lung Cancer.. A trial of chemotherapy and hydroxychloroquine for small cell.. Hydroxychloroquine is a substance that decreases immune responses in the body. Palbociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Estrogen can cause the growth of breast cancer cells. Drugs, such as letrozole, may lessen the amount of estrogen made by the body. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Staging scans do not show evidence of metastatic disease. He is scheduled to undergo a laparoscopic hemicolectomy. The patient has a 15-year history of rheumatoid arthritis, currently well controlled on hydroxychloroquine, methotrexate, and 7.5 mg daily of oral prednisone; he has been treated with this regimen continuously for the last 5 years.