Chloroquine phosphate, 250 mg twice daily, or hydroxychloroquine sulfate, 200 mg twice daily, was administered for a period of 6 to 21 months. Patients had regular clinical evaluation, determination of serum and cerebrospinal fluid angiotensin-converting enzyme level, computed tomography or magnetic resonance imaging, chest radiography, lung function testing, and slit-lamp examination of the eyes. Plaquenil and methotrexate taken together Hydroxychloroquine side effects mayo clinic Plaquenil itchy hands and feet Can plaquenil cause ankle swelling Apr 05, 2010 if you go on plaquenil please know that you will require Opthalmological exams to make sure there are no changes to the eye from it. it can cause optic nerve damage. Methtorexate is given for any ocular inflammatory disease such as uveitis. Beyond Plaquenil, he said, it’s essential to “be aware of local or systemic toxicities from topical ocular medications—and ocular toxicities from systemic medications.” With regard to Plaquenil, Dr. Marmor said, “The best hope is that patients and their rheumatologists know this drug is toxic and tell the ophthalmologist about it. Jul 15, 2004 OPHTHALMOLOGIC SARCOIDOSIS. Acute anterior uveitis usually clears spontaneously or after treatment with topical corticosteroids.1, 2 Systemic corticosteroids are indicated for treatment of optic. Magnetic resonance imaging with gadolinium was most helpful in supporting the diagnosis of sarcoidosis and monitoring the course of the disease. Chloroquine or hydroxychloroquine either stabilized symptoms or controlled neurological symptoms in 10 of 12 patients. Cerebrospinal fluid abnormalities, including lymphocytosis, were seen in 3 patients. Plaquenil sarcoidosis uveitis How effective is Plaquenil for Sarcoidosis by duration., Rx Side Effects New Plaquenil Guidelines and More - American. Plaquenil and prednisone combinationHydroxychloroquine plaquenil 200 mg tabletPlaquenil dosing in renal failurePlasmodium falciparum resistance to chloroquine Mar 19, 2009 Antimalarials such as Plaquenil hydroxychloroquine, Sanofi Aventis and Aralen chloroquine, Sanofi Aventis can also be considered in patients with pulmonary sarcoid.1,6,9,10. Sarcoidosis is an enigmatic disease that may affect all body systems. The ocular manifestations of this condition are well documented. Sarcoidosis Mystery Unraveled - Review of Optometry. Sarcoidosis - American Family Physician. REFERENCES - UpToDate. Ocular supervision is needed, although the drug has not been reported to cause retinal damage. 25 Because hydroxychloroquine prevents insulin degradation in the liver, suppresses gluconeogenesis, and increases peripheral utilization of glucose, it is of particular value in patients with sarcoidosis with insulin-dependent diabetes who cannot tolerate corticosteroids and in those who develop unmanageable hyperglycemia because of corticosteroids. 26 Plaquenil was the 1st treatment outside of prednisone that I tried. And I've been on 400 mg from the start. I did fine on it for a quite a while until the sarc joint pain became full fledged rheumatoid arthritis and I had to add something else. Sarcoidosis is a disease that may affect many different organs of the body but mostly affects the lungs. The disease usually occurs in adults ages 20 to 40 years of age. Some people may develop uveitis as a complication of sarcoidosis. Uveitis is an inflammation of the uvea or blood-rich membranes in the eye.