She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. What is the difference between plaquenil and hydroxychloroquine Plaquenil helps fatigue Hydroxychloroquine alcohol Does plaquenil change ph Etinopathy were monitored for 6 months to 82 months after HCQ cessation with multimodal imaging including spectral domain optical coherence tomography and fundus autofluorescence imaging at 488 nm standard and 787 nm near-infrared autofluorescence. Tests of visual function including visual acuity, Humphrey visual field testing, and multifocal electroretinography mfERG were performed. Retinal!toxicity.and!it!has!largely!replaced!chloroquine!as!a!treatment!ofinflammatory!disease. Unfortunately.the!retinal!damage!from!these!medications. Jan 01, 2011 SriniVas Sadda, MD, is associate professor of ophthalmology at the Keck School of Medicine of the University of Southern California and the Doheny Eye is Director of the Medical Retina Unit, Ophthalmic Imaging Unit, Retinal Transplantation Laboratory and Digital Image Reading Center. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Retinal deposits plaquenil infared imaging Infrared imaging of sub-retinal structures in the human., Plaquenil toxicity-eye rounds edited FINAL WARD Chloroquine pigmentation Aug 06, 2014 Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is. Multimodal Imaging in Plaquenil Toxicity. Fundus Autofluoresence Imaging Principles and Applications. H35.381-383 Toxic Maculopathy Of Retina - Decision-Maker PLUS. Patients suspected of developing retinal toxicity should discontinue chloroquine therapy if possible and undergo further evaluation to confirm toxicity. Take-home points. Patients started on chloroquine or hydroxychloroquine for systemic inflammation are at low but real risk of retinal toxicity from these medications. Retinal imaging takes a digital picture of the back of your shows the retina where light and images hit, the optic disk a spot on the retina that holds the optic nerve, which sends. Sep 01, 2018 Over time, or with continued IV drug abuse, these deposits can lead to complications, such as retinal artery occlusion, neovascularization and vitreous hemorrhage, all of which can cause severe progressive vision loss. On SD-OCT, the crystalline deposits are observed as hyperreflective dots in the inner retina that distribute along the arteries.