Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil addictive Volume of distribution of chloroquine Chloroquine chemotherapy Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues. Muscle pain and muscle tenderness, especially during periods of increased disease activity flare, occur in as many as 50 percent of those with lupus. The symptoms may have different causes. It is important for your physician to determine the cause of your symptoms since treatments are quite varied. I was put on Plaquenil for RA as I was being dx for lupus. I am very mild. My rhuemy wants me to stop every time I have an infection. When it is gone she said I can resume at my own pace. Take into consideration I only take Plaquenil and ibuprofen 800mg. My symptoms came back after two weeks of being off it. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Discontinuing plaquenil now have muscle spasms What is the correct way to discontinue use of plaquenil?, How Lupus Affects the Muscles, Tendons and Joints Lupus. Generic plaquenil vs name brand The medications with a high risk of causing leg cramps are certain asthma medications and diuretics, but countless others can have muscle twitches and spasms as even a low-risk side effect. That said, no one should cease taking a medication without first consulting a doctor. Leading Causes Of Muscle Twitches And Spasms - HealthPrep. Stopping Plaquenil - General Discussion - Life With Lupus. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. I have PMR, but to get me to try to taper steroids, the rheum started me on generic Plaquenil. My right thigh muscle hurts, and walking up stairs is an issue - I can do it, but it hurts. I am trying to think back to if this was an issue when I was not on the Plaquenil - I have been on it for 4-5 months now, so it's hard to remember. In rare cases, Plaquenil can cause cardiomyopathy, a chronic disease of the heart muscle. If you're taking Plaquenil for an autoimmune condition, your symptoms should begin to improve after a few.