My rheumatologist is running tests but thinks I have a mixed connective tissue disease. I noticed plaquenil helping with my fatigue more so than anything else. I just want some relief from the knee, shoulder and wrist pain. It does help my joint pain but I need extra help from other meds too It can take up to 6 months to get in your system and fully work, each person is different. Plaquenil que es Plaquenil arthritis medicine Chloroquine md anderson Pct and hydroxychloroquine According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with arthritis. It can also reduce the incidence of joint damage, thus lessening the risk of developing a long-term disability from. Hello, I thought fatigue is one of the symptoms of RA, so taking the right medication should help lessen fatigue, shouldn't it? When I was diagnosed with RA 2.5 years ago, I experienced fatigue and really bad pain on my foot, but since I started Plaquenil and Orencia 2 years ago, I have been in medically induced remission and don't have fatigue anymore. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. If it does not help the joint pain be sure to talk to your doctor, there are other meds they can give you to help. From what I understand, it is "the first line of defense" and definitely worth a try! I pray it doesn't take that long for you to get some relief. Plaquenil was great for the pain and swelling but did almost nothing for the fatigue. Of all the meds, Plaquenil was the best for me and helped the most, but some people don't tolerate it. Plaquenil helps joint pain Plaquenil Uses, Dosage & Side Effects -, Plaquenil for fatigue and pain DailyStrength Quinacrine and hydroxychloroquine lupus profundus Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Lupus Medicines Hydroxychloroquine - Brigham and Women's Hospital. Plaquenil for joint pain -. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory pathways. Talk to your doctor about this, but my guess is that the Plaquenil is not doing anything to cause the pain, but rather that it is not doing enough to prevent it. It sounds like your RA has probably gotten a bit out of control, relative, to your current treatment, and Plaquenil is not a particularly potent drug when it comes to managing joint pain. These medications may also prevent lupus from spreading to certain organs, such as the kidney and central nervous system your brain and spinal cord and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives.