Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Opthamologist plaquenil eye exam montgomery al Chloroquin and ferroquine structure Hydroxychloroquine vidal Methotrexate is classified as a disease-modifying anti-rheumatic drug DMARD. The drug decreases pain and swelling associated with rheumatoid arthritis, slows progression of the disease, and helps prevent joint damage. When considering effectiveness and safety, is methotrexate injection better than oral methotrexate? I told my doctor I wanted to research a bit before I gave an answer. Do you think I should try the Plaquenil first before starting MTX or is it fine to jump to MTX? From what I read so far, seems like methotrexate is a bigger drug with more side effects so plaquenil would be the better choice. Any information would be helpful. Methotrexate vs plaquenil side effects long term and short term The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. But the Dr suggested I try Methotrexate instead. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Is plaquenil safer than methotrexate Choosing Medications for Rheumatoid Arthritis - NCBI Bookshelf, MTX vs Plaquenil - Arthritis Information Chloroquine or proguanilNaproxen and hydroxychloroquineAnti malaria pills chloroquineSjogren's pregnancy heart block hydroxychloroquineChloroquine toxicity cells Clinical practice guidelines recommend use of combination DMARDs such as hydroxychloroquine plus methotrexate for patients with a disease duration less than 6 months and moderate disease activity and poor prognostic features and is an option for high disease activity and poor prognostic features. Plaquenil hydroxychloroquine sulfate dose, indications.. Methotrexate vs plaquenil side effects long term and short term. Methotrexate or Plaquenil - Scleroderma - Inspire. Your doctor may prescribe methotrexate alone. or you may also take other drugs like aspirin, nonsteroidal anti-inflammatory drugs, low-dose steroids, or other disease-modifying antirheumatic drugs. Methotrexate–hydroxychloroquine combination therapy may cause lower disease activity in early RA than methotrexate monotherapy. Methotrexate monotherapy as first early RA treatment seems to lead to more treatment intensification. Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working.