Estrogen use should be discontinued unless its need outweighs its adverse effects on porphyrin metabolism. After achievement of remission, estrogen therapies may be cautiously reinstituted; however, the duration of remissions may be shortened. Difference chloroquine bafilomycin a1 Chloroquine syrup brand name Plaquenil side effects dizziness Undifferentiated connective tissue disease hydroxychloroquine Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. Hydroxychloroquine and phlebotomy were compared in the treatment of porphyria cutanea tarda PCT. Thirty patients received hydroxychloroquine 200 mg twice weekly for 1 year and thirty‐one underwent twice‐monthly phlebotomies of 400 ml whole blood each, also for 1 year. Clinical signs of disease improved equally in both groups. Porphyria cutanea tarda PCT typically is acquired rather than inherited, although the enzyme deficiency may be inherited. Certain triggers that impact enzyme production — such as too much iron in the body, liver disease, estrogen medication, smoking or excessive alcohol use — can cause symptoms. If symptoms recur, re-treatment can restore remissions. Remissions may last from several months to many years. Why hydroxychloroquine for porphyria cutanea tarda Porphyria NIDDK, Hydroxychloroquine versus phlebotomy in the treatment of. Billing oct for plaquenil Plaquenil hydroxychloroquine Disease Interactions. There are 8 disease interactions with Plaquenil hydroxychloroquine The use of 4-aminoquinolines is generally considered contraindicated in the presence of retinal or visual field changes, whether attributable to 4-aminoquinoline compounds or to any other etiology. Plaquenil hydroxychloroquine Disease Interactions -. Porphyria - Symptoms and causes - Mayo Clinic. Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy in Treatment.. Most of the symptoms of porphyria cutanea tarda appear on the skin. Common symptoms include blisters on skin that’s exposed to the sun, including the hands, face, and arms. photosensitivity, which means your skin is sensitive to the sun. thin or fragile skin. increased hair growth, usually on the face. Porphyria cutanea tarda commonly referred to as PCT is recognized as the most prevalent subtype of porphyritic diseases. The disease is characterized by onycholysis and blistering of the skin in areas that receive higher levels of exposure to sunlight. The primary cause of this disorder is a deficiency of uroporphyrinogen decarboxylase UROD, a cytosolic enzyme that is a step in the enzymatic pathway that leads to the synthesis of heme. Porphyria cutanea tarda PCT is a rare disease, with a strong association with hepatitis C virus. PCT is particularly problematic in end-stage renal disease patients as they have no renal excretion of porphyrins and these are poorly dialyzed.