Previously referred to as “Resochin”, Chloroquine was first discovered in 1924 at Bayer laboratories. Its first use was initially ignored as it was found to be toxic to people. Chloroquine hair loss Plaquenil main side effects Chloroquine-resistant Plasmodium falciparum CRPF malaria is a potential threat to the health of approximately 1000 Amcerican Peace Corps Volunteers PCVs in West Africa. Minimizing that threat requires accurate and up-to-date information on the geographical extent of CRPF so that prophylaxis recommendations and treatment protocols can be. Chloroquine, used at recorded levels 190 tons hundreds of millions of treatment courses in Africa alone each year, has been a tremendous force driving the widespread replacement of chloroquine-sensitive by chloroquine-resistant P. falciparum. Travel to areas with chloroquine-resistant malaria Chloroquine-resistant P. falciparum is found in all parts of the world except the Caribbean and countries west of the Panama Canal. Although chloroquine-resistant P. falciparum predominates in Africa, it is found in combination with chloroquine-sensitive P. vivax malaria in South America and Asia. These trials showed that chloroquine eliminated malaria and was appropriate to be used as an antimalarial drug. Thus, it was not until World War II that the government of the United States sponsored the clinical trials of chloroquine as an antimalarial drug. Chloroquine-resistant malaria is now widespread in africa Malaria Travel & Health Guide, 2019 Online Book, Chloroquine-Resistant Malaria The Journal of Infectious. Chloroquine phosphate 250 mg malaria If artemisinin resistance becomes widespread in Africa, as has happened with other antimalarial drugs such as chloroquine, then the public health consequences would be catastrophic and it is likely there would be a reversal in the recent declines seen in malaria mortality. How is malaria treated and prevented? Facts. Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health.. Drug-resistant malaria reaches Southeast Asia borders, could spread to.. For the last decade chloroquine-resistant Plasmodium falciparum CRPF has spread explosively in sub-Saharan Africa. In some areas of the continent, CRPF is so intense that chloroquine can hardly be said to have any efficacy. Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases it can cause yellow skin, seizures, coma, or death. Symptoms usually begin ten to fifteen days after being bitten by an infected mosquito. Chloroquine was the most common anti-malarial used according to surveys from 14 of 21 countries analysed, predominantly in West Africa. SP was most commonly reported in two of 21 countries.