Nevertheless, retinopathy begins to appear with long-term use, and retinopathy is serious insofar as there is no known treatment. It can progress for a year or more after stopping the drug and, if not recognized early (at the point of screening), it can lead to functional blindness. Hydroxychloroquine solubility Taking hydroxychloroquine for lupus Prophylaxis of malaria chloroquine Upon physical examination, there is a bilateral change in the retinal pigment that may give the appearance of a bulls-eye 2, 3. Treatment If the patient manifests the toxicity symptoms of Plaquenil, the standard of care is to stop taking the medication and to change the medication the patient is taking. Taking Hydroxychloroquine develop toxicity2 It’s rare for side effects to occur with Plaquenil if the medication is dosed properly Side effects Blurred vision, bull’s eye maculopathy, scotoma, vortex keratopathy, headache, accommodative dysfunction, whitening of eyelashes, phototoxicity3 Founded in the UK by optometrists Doug and Dame Mary Perkins in 1984, Specsavers now has more than 1,700 stores across 10 countries. With over 380 stores across Australia and New Zealand making high-quality eye care and hearing care accessible to all, Specsavers is the market leader in Aus/NZ retail optics and is fast establishing itself within the audiology market. Hydroxychloroquine, sold under the brand name Plaquenil (Sanofi-Aventis), is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. The classic clinical picture of HCQ toxicity is a “bull’s eye” maculopathy (see Figure 1)—but as I’ll later note, this is a late finding. Plaquenil bull's eye retinopathy Chloroquine retinopathy - Wikipedia, Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy Plaquenil toxicity ocularCornea verticillata hydroxychloroquine Sep 15, 2014 The retinopathy, funduscopically visible bull’s eye maculopathy, indicates that severe toxicity has determined irreversible degeneration of the retinal pigment epithelium and since it is already a late stage, a screening test is not necessary anymore. Retinal toxicity associated with chronic exposure to.. Optometry case study Bull's eye maculopathy - Spectrum ANZ. Hydroxychloroquine Retinopathy Still Alive and Well - The.. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. In some people, Plaquenil can cause a condition called hydroxychloroquine retinopathy, often referred to as bulls-eye maculopathy. The condition sometimes resembles a target, or bulls-eye ring, on the retina surrounding the macula. Hydroxychloroquine retinopathy is extremely rare and is most often seen in cases where the dosage is high or the. However, these findings do not explain the clinical pigmentary changes causing a bull’s-eye maculopathy. Medication Dosage. Several factors have been associated with the risk of developing hydroxychloroquine retinopathy. One of the most important appears to be dosage—with debate over whether daily intake vs. cumulative dosage is most.