Chloroquine mode of action malaria

Discussion in 'Chloroquine Phosphate' started by waterfall, 09-Mar-2020.

  1. alex812 Well-Known Member

    Chloroquine mode of action malaria


    Inhibition of protein synthesis is also observed, evidently as a secondary effect. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine.

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    Chloroquine is an antimalarial drug. Malaria invade RBCs and degrade the hemoglobin to utilize their amino acids. However heme molecules are toxic to malarial cells, therefore malaria polymerize. The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial. Chloroquine is the drug of choice in the few malaria-endemic areas free of CRPf. Combining chloroquine and proguanil is an option for CRPf when other first-line antimalarials are contraindicated. Dosage should be calculated in terms of the base. The adult chloroquine dose is 300 mg base weekly or in some countries 100 mg base daily.

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    Chloroquine mode of action malaria

    Chloroquine Mechanism of action and resistance in malaria., Chloroquine mechanism of drug action and resistance in.

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  5. This study explains malaria origin and presents Plasmodium evolution and chloroquine mode of action on parasite. Hypotheses on the chloroquine resistance mechanism and reversion of antimalarial.

    • Malaria Mode of action of chloroquine and mechanism of..
    • Chloroquine - an overview ScienceDirect Topics.
    • PDF Chloroquine Modes of action of an undervalued drug.

    Apr 24, 2018 Learn about Chloroquine Mechanism of action and resistance in 2 minutes. Presenter Dr. Tanmay Mehta MD, DNB, PGDCTM Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain. In this review, a hypothesis is presented that can explain much of the confusing detail concerning the Chloroquine in Plasmodium faleiparum 205 specific antimalarial action of chloroquine. As the mechanism of action appears to be distinct from the mechanism of resistance, this identifies a vulnerable target for the development of new.

     
  6. InetSol XenForo Moderator

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  8. Mansur Well-Known Member

    Plaquenil vs. Prednisone Prescription Treatment for. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form.

    Hydroxychloroquine Plaquenil
     
  9. WMDrakon Guest

    Hydroxychloroquine Plaquenil Side Effects & Dosage for. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Side effects, drug interactions, pregnancy safety information, and dosage information should be reviewed prior to taking this medication.

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