ABSTRACT: QT prolongation is a rare adverse event associated with many drugs, including antipsychotics and antidepressants. Effects of milnacipran on cardiac repolarization in healthy participants. Typical antipsychotics have been implicated in many cases of torsades de pointes and QTc prolongation. A placebo- and active-controlled assessment of 6- and 50-mg oral doxepin on cardiac repolarization in healthy volunteers: a thorough QT evaluation. Hydroxychloroquine in type 2 diabetes Taking methotrexate and plaquenil DRUGS TO BE AVOIDED BY CONGENITAL LONG QT PATIENTS CredibleMeds® has reviewed all available evidence and has placed the following drugs in designated risk categories for their risk of causing torsades de pointes TdP Known Risk of TdP KR, Possible Risk of TdP PR, Conditional Risk of TdP CR or Special Risk SR. Marked prolongation of QT interval in a 15-year-old male adolescent with long QT syndrome LQTS R-R = 1.00 s, QT interval = 0.56 s, QT interval corrected for heart rate QTc = 0.56 s. As PLAQUENIL may enhance the effects of a hypoglycemic treatment, a decrease in doses of insulin or antidiabetic drugs may be required. Drugs That Prolong QT Interval And Other Arrhythmogenic Drugs. PLAQUENIL prolongs the QT interval and should not be administered with other drugs that have the potential to induce cardiac arrhythmias. Tricyclic and tetracyclic antidepressants and selective serotonin reuptake inhibitors have also been linked to QTc prolongation. Psychotropic drugs associated with corrected QT interval prolongation. Most atypical antipsychotics are considered to have a better cardiac profile. Plaquenil qt prolongation Long QT and Hydroxychloroquine; A Poorly Recognised Problem., How is asymptomatic long QT syndrome LQTS managed? Chloroquine phosphate puffer fishChloroquine lysosomal inhibitor transfectionClinical pharmacology of chloroquinPlaquenil hot flashes PLAQUENIL prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side effects. PLAQUENIL Dosage & Rx Info Uses, Side Effects. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Interactions between Plaquenil Oral and hydroxychloroquine.. In patients with risk factors for QT prolongation, hydroxychloroquine should be used with care. Reassessment of treatment should occur should any new risk factors for QT prolongation be identified for individual patients. Further information on risk factors for QT prolongation is available in a previous issue of Prescriber Update 5. If you are taking any drugs that can cause a certain type of heartbeat that is not normal prolonged QT interval. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure. This is not a list of all drugs or health problems that interact with hydroxychloroquine. The post HCQ ECGs had a mean QTc interval of 449 ms range 387-620. The mean change in QTc was 25 ms range 66-143. Overall 4 patients had a long QTc prior and 8 patients after initiation of HCQ therapy table 1. 8 patients were also taking ≥1 medication known to prolong the QT interval.