It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Plaquenil and maculopathy Any side effects from stopping plaquenil Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days. The recommended adult dosage is 200 to 400 mg 155 to 310 mg base daily, administered as a single daily dose or in two divided doses. Doses above 400 mg a day are not recommended. The incidence of retinopathy has been reported to be higher when this maintenance dose is exceeded. Initial dose 400 mg 310 mg base orally 1 to 2 times a day; this dose may be continued for several weeks or months, depending on patient response. Maintenance dose 200 to 400 mg 155 to 310 mg base orally daily. Comments -Each dose should be taken with a meal or a glass of milk. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Maximum dose of plaquenil Hydroxychloroquine Plaquenil, Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Hydroxychloroquine and neuropathyChloroquine phosphate effects on fishHydroxychloroquine and pres Daily dose greater than 400 mg or, in people of short stature, a daily dosage over 6.5 mg/kg ideal body weight or total cumulative dose of more than 1,000 g medication use longer than five years concomitant renal or liver disease because the drug is cleared by both routes Hydroxychloroquine-Induced Retinal Toxicity - American.. Hydroxychloroquine Dosage Guide with Precautions -. Plaquenil - FDA prescribing information, side effects and uses. Plaquenil Dosage The recommended Plaquenil dosage for malaria prevention is 400 mg once weekly, starting two weeks before the anticipated exposure. The usual starting dosage for treating lupus is 400 mg once or twice a day, and the recommended starting dose for the treatment of rheumatoid arthritis is 400 to 600 mg daily. In a second recently reported study, researchers from the Chicago area documented that roughly half of the 554 rheumatology patients on hydroxychloroquine HCQ in a regional health system and seen by an ophthalmologist during 2009-2016 received an excessive dosage of the drug. Treatment of the acute attack— In adults, an initial dose of 800 mg = 620 mg base followed by 400 mg =310 mg base in six to eight hours and 400 mg =310 mg base on each of two consecutive days total 2 g hydroxychloroquine sulfate or 1.55 g base.