Misoprostol, sold under the brandname Cytotec among others, is a medication used to prevent and treat stomach ulcers, start labor, cause an abortion, and treat postpartum bleeding due to poor contraction of the uterus. Misoprostol is used for the prevention of NSAID-induced gastric ulcers. It acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell. Because other classes of drugs, especially H2-receptor antagonists and proton pump inhibitors, are more effective for the treatment of acute peptic ulcers, misoprostol is only indicated for use by people who are both taking NSAIDs and are at high risk for NSAID-induced ulcers, including the elderly and people with ulcer complications. Misoprostol is sometimes coprescribed with NSAIDs to prevent their common adverse effect of gastric ulceration (e.g. However, even in the treatment of NSAID-induced ulcers, omeprazole proved to be at least as effective as misoprostol, but was significantly better tolerated, so misoprostol should not be considered a first-line treatment. Misoprostol-induced diarrhea and the need for multiple daily doses (typically four) are the main issues impairing compliance with therapy. It causes uterine contractions and the ripening (effacement or thinning) of the cervix. Medical abortion has the advantage of being less invasive, and more autonomous, self-directed, and discreet. Applicants shall follow this procedure (for family members having not yet reached 18 years of Age, the Application form must be signed by a Parent o by a person having the legal custody): An APPLICATION FORM (with the Official Statement) must be duly compiled and submitted via the Official CISRI website together with a scanned passport-size photo JPEG Format (300 dpi), 3,5 cm (width) x 4,5 cm ( height) Alternatively it may be printed out and sent to CISRI Secretariat by post, together with a passport size-photo 3,5 cm (width) x 4,5 cm ( height) The Safe-conduct is renewable every five years by sending back the Safe-conduct to the CISRI Organization, together with a renewal form and the procedure can be repeated with no temporal limits, but every fifteen years the Safe-conduct booklet must be re-issued with an updated photo. 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