One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Aralen and food What are the side effects of hydroxychloroquine Meloxicam and plaquenil Tell your doctor immediately if any of these rare but very serious side effects occur severe stomach/abdominal pain, severe nausea/vomiting, easy bleeding/bruising, signs of infection e.g. fever, persistent sore throat, seizures, shortness of breath, swelling ankles/feet, extreme tiredness, dark urine, yellowing eyes/skin. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. Although the drug has a relatively safe systemic profile, its use is associated with an increased incidence of macular toxicity––particularly if an individual has been on Plaquenil therapy for many years. 1,2 Specifically, a 2010 study indicated that the overall risk of Plaquenil macular toxicity increases by about 2% for every 10 to 15. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil ful fiel derg severe Multimodal Imaging in Plaquenil Toxicity, Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Is plaquenil used to treat osteoarthritisPlaquenil helped my fatigueOther options for hydroxychloroquine plaquenilTreatment for eye issues after taking plaquenil Pharmacokinetics Following a single 200 mg oral dose of PLAQUENIL to healthy male volunteers, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 daysthe same study, the plasma peak concentration was 50.3 ng/mL reached in 3.74 hours with a half-life of 2963 hours 123.5 days. Plaquenil Concordia Pharmaceuticals Inc. FDA Package Insert. Is Damage Still Occurring? - Review of Optometry. Plaquenil and brainfog I just started on the. - LUPUS UK. This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. Patients should be warned to keep Plaquenil out of the reach of children, as small children are particularly sensitive to the 4-aminoquinolines. Plaquenil should be used with caution or not at all in patients with severe gastrointestinal, neurological or blood disorders. If such severe disorders occur during therapy, the drug should be stopped. Before using Plaquenil, tell your doctor if you are allergic to any drugs, or if you have psoriasis, porphyria, liver disease, alcoholism, or glucose-6-phosphate dehydrogenase G-6-PD deficiency. Take Plaquenil for the full prescribed length of time for malaria. Your symptoms may improve before the infection is completely cleared.