Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Ear pressure from plaquenil Plaquenil cardiomyopathy cardiac mri Chloroquine, although grouped with hydroxychloroquine in table 2 of this article, is not routinely used in the management of SLE either in or out of pregnancy due to increased tissue Chloroquine and hydroxychloroquine should not be used in combination due to the increased risk of ocular toxicity. The antimalarial drugs may prevent the development of systemic lupus erythematosus SLE in patients with DLE, and they might decrease the risk of cardiovascular disease. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine use in sle Treating Lupus with Anti-Malarial Drugs Johns Hopkins., Discoid Lupus Erythematosus Medication Antimalarial. Chloroquine and primaquine combinationChloroquine phosphate anemonesGeneric plaquenil pillsPlaquenil retinal toxicity cumulative dose calculatorPlaquenil botox interaction The aminoquinolones chloroquine and hydroxychloroquine have been widely used in the treatment of SLE. These drugs can cause a reversible, visually insignificant keratopathy cornea verticillata and, more importantly, an irreversible sight-threatening maculopathy. Chloroquine Retinopathy - an overview ScienceDirect Topics. Hydroxychloroquine DermNet NZ. Hydroxychloroquine - Wikipedia. Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and chloroquine in the treatment of rheumatoid arthritis RA, systemic lupus erythematosus SLE and other. Chloroquine is a medication first developed as an anti-malarial that has been used for many years to help treat lupus systemic lupus erythematosus, or SLE and rheumatoid arthritis. If a patient responds to treatment with an anti-malarial, in general it will continue to be used indefinitely. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm.