Chloroquine phospahe absorbance nm

Discussion in 'Hydroxychloroquine Plaquenil' started by ALexus-8, 27-Feb-2020.

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    Chloroquine phospahe absorbance nm


    The method consists of recording the UV absorbance of the sample at a wavelength of 343 nm and comparing it to the absorbance of a reference standard in a concentration range representing a 100% label claim at the same wavelength. The method was adapted in such a way that it was possible to determine the quantity of the different salt forms of chloroquine in the tablets, where applicable.

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    Medscape - Indication-specific dosing for Aralen, Chloroquine phosphate chloroquine, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. The content of chloroquine was determined by UV-spectrophotometry in accordance with an adapted method for chloroquine phosphate tablets of the USP 24. The method consists of recording the UV absorbance of the sample at a wavelength of 343 nm and comparing it to the absorbance of a reference standard in a concentration range representing a 100%.

    Interference from excipients was validated by superimposing the UV spectra of the sample and standard. As all USP methods are specific for the analyte, the method was only validated in terms of precision.

    Chloroquine phospahe absorbance nm

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  5. Analytical wavelength343 nm bile phase to obtain a solution having a known concentra-Standard solutionUSP Chloroquine Phosphate RS in tion of about 1.5µg per mL. Medium Test solution—Proceed as directed for Assay preparation in Sample solutionDilute with Medium to a concentrationthe Assay. that is similar to the Standard solution.

    • Chloroquine / Official Monographs.
    • The Quality of Antimalarials - A Study in Selected African..
    • Hemoglobin Denaturation in the Presence of Chloroquine Phosphate.

    The ratio of the absorbance of a 1-cm layer at 257 nm to that at 343 nm is between 0.77 and 0.85, and the ratio of the absorbance at 329 nm to that at 343 nm is between 0.86 and 0.95. B. To 1 mL of a 20 mg/mL solution add 3 mL of nitric acid ~130 g/l TS; yields reaction A described under 2.1 General identification tests as characteristic of. Sensitive and Selective Extraction-Free Spectrophotometric Assay of Chloroquine Phosphate in Pharmaceuticals Based on Ion-Pair Reaction with Bromocresol Green and Bromocresol Purple Absorbance measured after 5 min at 420 nm against the reagent blank. In each case, calibration curve was prepared by plotting absorbance vs concentration, and concentration of the unknown was deduced from the regression equation derived from Beer's law data. Procedure for dosage forms Tablets An amount of pulverized chloroquine phosphate tablets

     
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