Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Does hydroxychloroquine affect immune system Plaquenil safe during pregnancy With all of the physical and emotional complications that lupus can cause, it’s easy to overlook symptoms that seem minor at first. But take this advice Don’t ignore changes in vision. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage. Dr Bernatsky Some studies have suggested that hematologic indices, like hemoglobin and platelet counts, might be markers of lymphoma risk, but many people who have SLE will have abnormalities in their white cell counts, hemoglobin, or platelets, and almost all of those people will not develop lymphoma. Our team is studying this issue, especially trying to see if there are antibodies that might correlate with or predict cancer risk. Study Raises Questions about Sjogren's and Plaquenil. For many patients with Sjogren's, Plaquenil hydroxychloroquine has long been the go to drug that their doctors prescribe. It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Does hydroxychloroquine cause lymphoma Increased Risk of Lymphoma With Rheumatoid Arthritis, Lymphoma in Patients With Systemic Lupus Erythematosus. Hydroxychloroquine side effects weight gain This causes too many diseased and ineffective lymphocytes in your lymph nodes and causes the lymph nodes, spleen and liver to swell. Risk factors. Factors that can increase the risk of lymphoma include Your age. Some types of lymphoma are more common in young adults, while others are most often diagnosed in people over 55. Being male. Lymphoma - Symptoms and causes - Mayo Clinic. Study Raises Questions about Sjogren's and Plaquenil. Hydroxychloroquine-Associated Hyperpigmentation Mimicking.. The Arthritis Foundation is focused on finding a cure and championing the fight against arthritis with life-changing information, advocacy, science and community. We can only achieve these goals with your help. Strong, outspoken and engaged volunteers will help us conquer arthritis. Autophagy and cancer. A large body of evidence suggests that the relationship between autophagy and cancer is complex.42, 43 On the one hand, autophagy appears to inhibit malignant transformation, reflecting its capability to limit the accumulation of potentially oncogenic entities like depolarized mitochondria which overproduce potentially genotoxic reactive oxygen species, ROS. Hydroxychloroquine treats malaria, systemic lupus erythematosus, rheumatic disorders like rheumatoid arthritis, porphyria cutanea tarda, and Q fever. 1 In 2014, its efficacy to treat Sjögren syndrome was questioned in a double-blind study involving 120 patients over a 48-week period.