Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil and lichen planus Chloroquine brain tumor Can plaquenil lower antibodies to thyroid Chloroquine diphosphate salt chem-impex Ideal Body Weight for Calculating Hydroxychloroquine Dosage. The most important risk factor for hydroxychloroquine retinopathy is the daily dose of the drug. If a patient is overweight, one should use the ideal body weight to assess whether the doaily dose is in the toxic range /= 6.5 mg/kg/day. Nov 09, 2018 Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America. Once thought to be safe at a daily dose of 6.5mg/kg/day 16, newer studies show that many years of hydroxychloroquine treatment at a "safe dose" can still lead to toxicity 6. Newer guidelines state that daily dose 5mg/kg of real weight/day can lead to toxicity. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Hydroxychloroquine real weight safe dose Hydroxychloroquine Side-effects, uses, time to work, Hydroxychloroquine - Side Effects, Dosage, Interactions. Plaquenil treatment for scleroderma He pointed out that these findings have been validated in several studies using other patient populations. He concluded that the risk is very real of developing retinal toxicity with prolonged use of hydroxychloroquine. The dose, duration, presence of renal disease and use of other drugs such as tamoxifen all contribute to the increased risk. The 2018 ACR Great Debate Hydroxychloroquine Dosing for SLE. Hydroxychloroquine Plaquenil Toxicity and.. ACR Actual-weight hydroxychloroquine dosing works in SLE, up.. Chloroquine is often part of a multi-drug regimen with other anti-parasitic medications. A cumulative dose of over 460 g or a daily dose of 2.3 mg/kg body weight/day is high risk. The latest studies show that using the patient's real weight instead of ideal weight correlates better with safe dosing. Chloroquine is rarely an option for rheumatic. Mg 620 mg base followed by 400 mg 310 mg base at 6 hours, 24 hours and 48 hours after the initial dose total 2000 mg hydroxychloroquine sulfate or 1550 mg base. Weight Based Dosage In Adults And Pediatric Patients Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more.