Chloroquine glutathione synthase

Discussion in 'Hydroxychloroquine Sulfate 200 Mg' started by Morfeus_1, 17-Mar-2020.

  1. LHAV New Member

    Chloroquine glutathione synthase


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Pathway i glutathione biosynthesis This protein is involved in step 2 of the subpathway that synthesizes glutathione from L-cysteine and L-glutamate. Proteins known to be involved in the 2 steps of the subpathway in this organism are Glutamate--cysteine ligase catalytic subunit, Glutamate--cysteine ligase regulatory subunit Glutathione synthetase, Glutathione synthetase, Glutathione. Glutathione synthase GSH2; EC 6.3.2.3. In Arabidopsis, GSH1 is exclusively targeted to the plastid, while GSH2 is targeted to both plastid and cytosol 12. Consequently, the pathway intermediate, γ-glutamylcysteine γ-EC, must be exported from the plastid to allow for cytosolic GSH biosyn-thesis. Glutathione synthetase is also a potent antioxidant. It is found in many species including bacteria, yeast, mammals, and plants. In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, increased rate of haemolysis.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine glutathione synthase

    Glutathione synthetase deficiency - Genetics Home Reference - NIH, Plant homologs of the Plasmodium falciparum PfCRT, are

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    Mutants lacking glutathione synthetase, which is the second enzyme of glutathione synthesis and is encoded by the GSH2 gene, have no GSH and are not viable. However, gsh2 mutants can be fully complemented by expression of GSH2 in the cytosol Pasternak et al. 2008, showing that expression in the cytoplasm is sufficient to restore the wild‐type growth phenotype. Xylina T. Gregg, Josef T. Prchal, in Hematology Seventh Edition, 2018. Glutathione Synthetase Deficiency. Glutathione synthetase GS deficiency is a slightly more common enzymopathy of glutathione metabolism than GCL deficiency. The clinical severity is variable, but approximately 25% of the patients die in childhood. To investigate the association between amplification of the two regulatory genes controlling glutathione GSH levels, glutathione reductase PfGR and glutathione S-transferase PfGST genes and sensitivity of Plasmodium falciparum P. falciparum isolates collected from different malaria endemic areas of Thailand to standard antimalarial drugs.

     
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