Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Visual field testing for plaquenil toxicity Plaquenil and weight loss Mechanism Hydroxychloroquine is thought to improve symptoms of systemic diseases by preventing inflammation. For example, to treat both rheumatoid arthritis and systemic lupus erythematosus SLE, it has been hypothesized that the drug suppresses T-lymphocytes by increasing the pH inside lysosomes, which disables leukocyte chemotaxis. This prevents leukocytes from being activated which decrease the inflammation seen in many systemic diseases. The many mechanisms for the hypoglycemic effects of antimalarials 10. These properties have demonstrated clinical efficacy in noninsu-lin-dependent patients, including those refrac-tory to sulfonylureas 11. Lupus patients benefit from these properties as well. In the Hopkins lupus cohort, for example, treatment with What is hydroxychloroquine Plaquenil, and how does it work mechanism of action? Hydroxychloroquine is classified as an anti-malarial drug. It is similar to chloroquine Aralen and is useful in treating several forms of malaria as well as lupus erythematosus and rheumatoid arthritis. Its mechanism of action is unknown. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil lupus mechanism Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus., Antimalarials in systemic lupus erythematosus benefits. Plaquenil breastfeeding halePlaquenil cost canadaOptic neuropathy due to plaquenilWhat is the half life of chloroquine The mechanism of action is thought to be anti-inflammatory, but Plaquenil also seems to reduce sensitivity to sunlight. It has also been noted recently that smoking reduces the effectiveness of Plaquenil in treating lupus, thus, smoking cessation should be instituted in all patients taking Plaquenil. Plaquenil Use in Autoimmune Diseases. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Hydroxychloroquine - an overview ScienceDirect Topics. These medications may also prevent lupus from spreading to certain organs, such as the kidney and central nervous system your brain and spinal cord and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives. Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Low blood concentration of hydroxychloroquine is a marker for and predictor of disease exacerbations in patients with systemic lupus erythematosus. Arthritis Rheum 2006; 84. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth.