Lysosomes ph and the antimalarial action of chloroquine

Discussion in 'International Pharmacy' started by ask812, 04-Mar-2020.

  1. GalaXyMan Well-Known Member

    Lysosomes ph and the antimalarial action of chloroquine

    For decades, the drug was a front-line treatment and prophylactic for malaria. In a three-page paper published Tuesday in Cell Research, scientists at the Wuhan Institute of Virology’s State Key Laboratory of Virology write that both chloroquine and the antiviral remdesivir were, individually, “highly effective” at inhibiting replication of the novel coronavirus in cell culture.

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    Chloroquine raises the pH in host-cell lysosomes, which interferes with viruses’ attempts to acidify the lysosomes, a prerequisite to formation of the autophagosomes that cells use to eat themselves. In the Cell Research paper, the researchers found that the drug was effective at inhibiting the virus as it was both entering and exiting cells. Krogstad DJ, Schlesinger PH. The basis of antimalarial action non-weak base effects of chloroquine on acid vesicle pH. Am J Trop Med Hyg. 1987 Mar; 36 2213–220. Krogstad DJ, Schlesinger PH. Acid-vesicle function, intracellular pathogens, and the action of chloroquine against Plasmodium falciparum. N Engl J Med. 1987 Aug 27; 317 9542–549. In this video, I will explain into one of the main antimalarial drug, chloroquine. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive.

    “It’s interesting in that it really lacks a lot of details but, nevertheless, if you look at the data as presented, at least in vitro, it seems like chloroquine can be used as an early-stage drug,” he said. Their drug screen evaluated five other drugs that were not effective. Though the paper is brief, John Lednicky, a professor at the University of Florida’s Emerging Pathogens Institute, found its results intriguing.

    Lysosomes ph and the antimalarial action of chloroquine

    Chloroquine as Intercalator a Hypothesis Revived, Antimalarial agents mechanisms of action.

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  5. The resulting slight elevation in endosomal pH in macrophages may influence the assembly and trafficking of molecules important in immune regulation. This hypothetical model of antimalarial drug action suggests methods for screening additional drugs for the ability to modulate the immune response.

    • PDF Lysosomes, pH and the antimalarial action of chloroquine.
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    Chloroquine and ammonium chloride, by virtue of their basic properties, have been shown to raise endocytic and lysosomal pH and thereby interfere with normal iron metabolism in a variety of cell types, including mononuclear phagocytes. Cellular iron metabolism is of critical importance to Legionella pneumophila. Lysosomes and drug resistance in malaria. The introduction of chloroquine for malaria in the late 1940s was a great advance on quinine and mepacrine. It was cheap, non-toxic, and soon became the mainstay of therapy and prevention. For 10 years it was used successfully throughout the tropics. Oct 01, 2018 C 18 H 26 ClN 3.2H 3 PO 4 Molecular Weight 515.87 Each tablet contains 500 mg of Chloroquine phosphate USP, equivalent to 300 mg Chloroquine base. Inactive Ingredients colloidal silicon dioxide, dibasic calcium phosphate, hydroxypropylmethylcellulose, magnesium stearate.

  6. Yamert User

    The risk of catching malaria is increased when you travel to a country that has a high-risk factor and haven't taken the proper precautions to prevent being bitten by mosquitoes. Boots Chloroquine and Proguanil Anti-Malarial Tablets. AVLOCLOR 250 MG TABLETS Malarone Pediatric Oral Uses, Side Effects, Interactions, Pictures.
  7. xxj Well-Known Member

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Plaquenil Dosage Guide - AMERICAN COLLEGE OF RHEUMATOLOGY Rx Side Effects New Plaquenil Guidelines and More.
  8. SSerGS XenForo Moderator

    Plaquenil, diarrhea and weight loss? - Sjogren's World I have been on Plaquenil and can tell you my diarrhea started within days of starting the med. My doctor warned me that diarrhea and weight loss were side effects. I said, "Well, I am usually very constipated and could stand to lose 10 pounds so this could be a good thing." haha. I am NOT constipated any more but have not lost any weight either. I can tell you, I will take the discomfort of diarrhea over the discomfort, bloatiness and hemorrhoids from constipation.

    Plaquenil aka HCQS – Anyone on this getting severe diarrhea.
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