It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Effect of chloroquine on liver enzymes Stopped plaquenil now symptoms have returned Assay of chloroquine by non aqueous titration I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks Tell your doctor if you experience serious side effects of Plaquenil including muscle weakness, twitching, uncontrolled movement, loss of balance or coordination, blurred vision, light sensitivity, seeing halos around lights, pale skin, easy bruising or. bleeding, confusion, unusual. Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and. Prescribed for Lyme Disease - Arthritis, Dermatomyositis, Malaria Prevention, Malaria, Rheumatoid Arthritis. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Side effects of plaquenil and methotrexate Methotrexate and plaquenil - @Kristinsaba1988 - Scleroderma., Plaquenil vs. Rheumatrex, Trexall Prescription Treatment. Chloroquine and fluoroquinolone dissertationHydroxychloroquine 200 mg dosagePlaquenil empty stomachChloroquine phosphate in display tank I was on both medis for 15 years for mixed connective disease. I recently stopped methotrexate due to lungs involvement, my pulmonologist decided to put me on cellcept.i had no majors side effects but a metal taste when I first started. Make sure you have a chest X-ray yearly and periodic labs work. Good luck. Methotrexate and plaquenil - @Kristinsaba1988.. Methotrexate vs Plaquenil Comparison -. Hydroxychloroquine Side Effects Common, Severe, Long Term.. In defense of your ophthalmologist, the eye problems with Plaqueni, although rare are dose related. Comparison of Plaquenil and methotrexate is difficult. Both drugs are very well tolerated and have different side effects, but if you have other medical problems, one drug might be better for you and you should discuss this with your rheumatologist. GI problems such as nausea and vomiting are the most common side effects associated with methotrexate, affecting between 20and 65 percent of RA patients who take the drug. While hair loss is a relatively uncommon side effect in patients who take methotrexate at such doses, up to one third develop mouth ulcers, or sores. Side-effects aren't common. However, in some people hydroxychloroquine can cause skin rashes, especially those made worse by sunlight; feeling sick nausea or indigestion; diarrhoea; headaches; bleaching of the hair or mild hair loss; tinnitus ringing in the ears visual problems.