Chloroquine cell death

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  1. koz Well-Known Member

    Chloroquine cell death

    Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention.

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    Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis. The present study investigated the interaction of zinc ions with chloroquine in a human ovarian cancer cell line. Autophagy1 is a complex of adaptive cellular response that enhances cancer cell survival in the face of cellular stresses such as chemothery. Here we show that in human gallbladder carcinoma GBC cells lines, SGC-996 and GBC-SD, autophagy is induced by the DNA damaging agent 5-fluorouracil 5-FU. While in combination with the pre-treatment of chloroquine CQ, a inhibitor of autophagy, the. Jan 25, 2018 Gene mutations and focal amplification are genetic changes that modulate the sensitivity of tumors to the induction of cell death, and, therefore, differences in treatment sensitivity may depend.

    Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine.

    Chloroquine cell death

    Chloroquine-induced autophagic vacuole accumulation and cell., Suppression of autophagy by chloroquine. - Cell & Bioscience

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  3. Neuronal cell death following chloroquine-induced impairment of autophagic clearance did not require caspase activity, as indicated by the lack of a significant effect of the pan-caspase inhibitor.

    • Impaired autophagosome clearance. - Cell Death & Disease.
    • Cell death-based treatment of lung adenocarcinoma Cell..
    • Frontiers Re-purposing Chloroquine for Glioblastoma..

    Chloroquine is a lysosomotropic agent that prevents endosomal acidification. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. Oct 13, 2016 Protection from ADI-PEG20 and chloroquine-induced cell death also resulted following shRNA-mediated knockdown of receptor-interacting protein 1 RIP1 or RIP3, further suggesting necroptosis as the mechanism of cell death upon treatment with ADI-PEG20 and chloroquine Figure 5b. Chloroquine-Mediated Cell Death in Metastatic Pancreatic Adenocarcinoma Through Inhibition of Autophagy Hermann B Frieboes 1,2, Justin S Huang 3, Wenyuan C Yin 3, Lacey R McNally 2,3 1 Department of Bioengineering, 2 James Graham Brown Cancer Center, and 3 Department of Medicine; University of Louisville.

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