In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Fishman's chemical chloroquine phosphate Chloroquine hydrochloride dose Right computation of taking plaquenil Does hydroxychloroquine suppress your immune system These medications may also prevent lupus from spreading to certain organs, such as the kidney and central nervous system your brain and spinal cord and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives. Yeast infections in the mouth should be treated with antifungal medications. Treat systemwide symptoms. Hydroxychloroquine Plaquenil, a drug designed to treat malaria, is often helpful in treating Sjogren's syndrome. Drugs that suppress the immune system, such as methotrexate Trexall, also might be prescribed. Plaquenil certainly has risks, though at the dose taken for Sjogren's they are relatively low. I've been on Plaquenil several times for a multiyear period, but never felt I got any benefit from it. Others here have had good results, and a few have had bad reactions. I don't know of a natural product that is chemically similar to plaquenil. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Alternatives to plaquenil for sjogrens Healthboards - Immune & Autoimmune - Lupus Alternatives to, Sjogren's syndrome - Diagnosis and treatment - Mayo Clinic Do chloroquine cause splenomegalyChloroquine breast cancer clinical trialHydroxychloroquine less common side effectsPlaquenil and diahreah Alternative and complementary therapies list for Sjogren's Syndrome Alternative treatments, complementary therapeutic options, or home remedies that have been listed in various sources as possibly helpful for Sjogren's Syndrome may include Homeopathic eye drops. Evening primrose oil. Gamma-linolenic acid GLA Vitamin C. Vitamin B6. Potassium. Alternative Treatments for Sjogren's Syndrome -. Natural alternatives to Plaquenil - Sjogren's World. Alternatives to plaquenil Anti-Inflammatories.. For many patients with Sjogren's, Plaquenil hydroxychloroquine has long been the go to drug that their doctors prescribe. It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. New Treatment Guidelines for Sjo¨gren’s Disease 535. treatment. This process involves the assessment of key ocular symptoms as described previously, as well as the examination of several objective parameters, including tear production, tear film stability, tear osmolarity, lid margin disease, and ocular surface damage. Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases. In Sjögren’s, Plaquenil is used to treat many symptoms.