Chloroquine maculopathy risk factors

Discussion in 'Plaquenil' started by timer007, 23-Feb-2020.

  1. vik31 Well-Known Member

    Chloroquine maculopathy risk factors


    Multifocal electroretinography testing in patient 4 demonstrating progressive generalized reduction in multifocal electroretinography amplitudes in both eyes when comparing responses recorded 2 years (A) after stopping hydroxychloroquine sulfate use with those 3 years later (B). Static visual field testing in patient 4 demonstrating progressive central visual field loss in both eyes, from first presentation (A: 30-2 Humphrey visual field) to 3 years (B: 10-2 Humphrey visual field) after stopping hydroxychloroquine sulfate use.

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    A recent retrospective study in 51 patients being treated with hydroxychloroquine and chloroquine re-evaluated the potential risk factors. Age and duration continued to be the major risk factors with smoking being negligible and BMI not being an issue. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. Other risk factors include Obesity; Duration of use cumulative dose Renal or hepatic functional impairment. Compromised kidney and/or liver function can lead to increased accumulation of hydroxychloroquine in the tissues. Age over 60 years. For higher-risk patients, annual screening should begin immediately i.e. without a 5-year delay. Annual Screening. Annual screening should be performed after 5 years of use in all patients and from the initiation of therapy for patients with maculopathy or unusual risk factors, as described in Table 1. It must be emphasized that these are.

    Central and peripheral visual field defects are more evident on static visual field testing (C) 3 years after cessation of hydroxychloroquine use compared with kinetic testing undertaken at the same visit (B). Kinetic visual field testing in patient 4 demonstrating progressive constriction of the visual field in both eyes for all isopters tested, from 13 months (A) to 3 years (B) after stopping hydroxychloroquine sulfate use.

    Chloroquine maculopathy risk factors

    Drug induced maculopathy - EyeWiki, Plaquenil Risk Calculators

  2. Chloroquine depensed to us troop in honduran
  3. Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs.

    • Chloroquine retinopathy - Wikipedia.
    • Revised Recommendations on Screening for Chloroquine and..
    • Hydroxychloroquine-Induced Retinal Toxicity - American..

    A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10. However, there have been case reports of patients with hydroxychloroquine toxicity as early as 1.9 months after starting treatment 11. Mar 10, 2017 A large study population permitted detailed analysis of risk factors with sub-group analysis such as risk of retinopathy in different ranges of doses by weight. The overall prevalence of HCQ retinopathy was 7.5%, but this increased to around 20% after 20 years of use for those taking 4.0–5.0 mg/kg ABW/day. However, while the toxicity is no doubt significantly reduced, the risk is still present and poses a significant clinical challenge. 3-5 Several risk factors have been identified that may increase the likelihood of hydroxychloroquine-related retinal toxicity 1 daily dosage exceeding 6.5 mg/kg, 2 obesity, 3 duration of use longer than 5.

     
  4. Vlad_ka User

    Description: An exception occurred while processing your request. Ototoxicity HealthEngine Blog American Ear Hearing and Audiology LLC - Ototoxic Medications List Ototoxicity of Chloroquine JAMA Otolaryngology–Head & Neck.
     
  5. qwertinnio New Member

    The page you are trying to reach is not available on our site. The page name may have changed, you may have happened upon a broken link, or the URL may be entered incorrectly. Hydroxychloroquine Plaquenil The Risk of Retinal Toxicity with Plaquenil Rx Side Effects New Plaquenil Guidelines and More.
     
  6. alexpilot User

    Drug-induced photosensitivity DermNet NZ Drug-induced photosensitivity occurs when certain photosensitising medications cause unexpected sunburn or dermatitis a dry, bumpy or blistering rash on sun- exposed skin face, neck, arms, backs of hands and often lower legs and feet. The rash may or may not be itchy.

    Adverse Cutaneous Reactions to Hydroxychloroquine Are More.
     
  7. UkrPromo2 Well-Known Member

    Hydroxychloroquine toxicity - EyeWiki Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1

    Multimodal Imaging in Plaquenil Toxicity