In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Does hydroxychloroquine lower blood sugar Plaquenil standard dose Plaquenil and weight loss What is drug-induced skin pigmentation. Drug-induced skin pigmentation accounts for 10–20% of all cases of acquired hyperpigmentation. Pigmentation may be induced by a wide variety of drugs; the main ones implicated include non-steroidal anti-inflammatory drugs NSAIDs, phenytoin, antimalarials, amiodarone, antipsychotic drugs, cytotoxic drugs, tetracyclines, and heavy metals. Pigmentation to manifestations of systemic illnesses e.g. Addison’s disease and malignant neoplasms e.g. melanoma and Kaposi’s sarcoma. Therefore, an understanding of the causes of mucosal pigmentation and appropriate evaluation of the patient are essential. Oral pigmentation may be exogenous or endogenous in origin. Drug-induced skin pigmentation is estimated to account for 10-20% of all cases of acquired dyspigmentation worldwide. Race. Drug-induced pigmentary changes can occur in persons of any race, but hypomelanosis is seen more frequently and appears more dramatically in patients with darker-pigmented skin. JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959)A, Bluish-green pigmentation on the legs in a patient with systemic lupus erythematosus without lupus lesions at the time of the skin biopsy. Rates and predictors of hydroxychloroquine retinal toxicity in patients with rheumatoid arthritis and systemic lupus erythematosus. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Chloroquine-induced pigmentation Chloroquine-induced pigmentation case reports., Pigmented Lesions of the Oral Cavity Review, Differential. What drug class is hydroxychloroquinePlaquenil for crest syndromeChloroquine interactionAralen mechanism of action Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ. Hydroxychloroquine-Induced Pigmentation in Patients With.. Drug-Induced Pigmentation - Medscape. Chloroquine-Induced Hypopigmentation of Hair and Freckles.. Hyperpigmentation of the Skin Following Chloroquine Treatment 71 DISCUSSION AND CONCLUSION The aforesaid pigmentary changes of the skin al-though, could be explained by the underlying disorder or other concomitantly administered drug predniso-lone, have followed reasonable temporal sequence to Pigmentation has been associated with drug therapy or adrenal insufficiency; however, in many cases the cause cannot be identified 15. The greatest significance of chloroquine-induced hyper-pigmentation is the possibility that it may be a marker for a more serious side effect. Irreversible retinopathy A case of hair depigmentation induced by chloroquine diphosphate subacute overdosage in an 11-year-old patient with dermatomyositis is presented. Normal coloured hair growth occurred after normalis.