I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Chloroquin Plaquenil method of action Side-effects of Prednisone. In the chapter Treating Lupus With Medications, I talked about prednisone as being the single most important factor in improving the outlook for lupus patients. It is a very powerful tool in the treatment of lupus, it is usually effective in bringing lupus under control and it saves lives. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. My Love-hate Relationship with Lupus and Prednisone. said he thinks I have Lupus and wrote a prescription for Plaquenil but at the last minute stopped and said he. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. Plaquenil and prednisone for lupus Plaquenil and Prednisone, Plaquenil vs. Prednisone Prescription Treatment for Rheumatoid. Plaquenil positive reviewsPlaquenil for infertilityChloroquine patient information leafletPlaquenil detoxingPlaquenil vaccines When I was first diagnosed with lupus I was put on prednisone and plaquenil to help control my severe joint inflammation. The prednisone began workiing in 3 days and helped reduce my joint inflammation. I had some issues with the plaquenil, nausea and extremity swelling. Prednisone/Plaquenil question -. My Love-hate Relationship with Lupus and Prednisone LupusChick. Prednisone for Lupus DailyStrength. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Hi, I JUst wanted to let you know that Plaquenil, and other lupus meds can be rough on your stomach.so in the beginning than long term. My doctor reccomended that I eat 100 calories at least prior to taking Plaquenil and Naproxen. I was prett nauseous the frist 2 weeks on these meds, but over time it diminished. A few years ago I was diagnosed with lupus. I currently take mtx, 1 mg of folic acid a day, hydroxychloroquine plaquenil and a low dose of prednisone, 5mg. Mtx is used to treat certain types of cancers but at much higher and frequent doses than to treat RA and lupus,where mtx is taken once a week and the average dose is about 15mg.